Assay Detail
Functional
CHEMBL1687249
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Cytotoxicity against human SNU638 cells by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-638 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.25 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.01 |
| CHEMBL1684623 | — | — | 1 | 5.87 |
| CHEMBL1684634 | — | — | 1 | 5.78 |
| CHEMBL123 | ELLIPTECINE | — | 1 | 5.66 |
| CHEMBL1684627 | — | — | 1 | 5.59 |
| CHEMBL1684628 | — | — | 1 | 5.49 |
| CHEMBL1684622 | — | — | 1 | 5.23 |
| CHEMBL1684633 | — | — | 1 | 5.16 |
| CHEMBL1684617 | — | — | 1 | 5.10 |
| CHEMBL1684629 | — | — | 1 | 5.08 |
| CHEMBL1684625 | — | — | 1 | 5.08 |
| CHEMBL1684631 | — | — | 1 | 5.04 |
| CHEMBL1684619 | — | — | 1 | 4.91 |
| CHEMBL1684620 | — | — | 1 | 4.72 |
| CHEMBL1684626 | — | — | 1 | 4.70 |
| CHEMBL1684630 | — | — | 1 | 4.65 |
| CHEMBL1684618 | — | — | 1 | 4.24 |
| CHEMBL1684621 | — | — | 1 | - |
| CHEMBL1684624 | — | — | 1 | - |
| CHEMBL1684632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1684623 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL1684634 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL123 | ELLIPTECINE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1684627 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL1684628 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL1684622 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL1684633 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL1684617 | — | IC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL1684629 | — | IC50 | = | 8240.0 | nM | 5.08 |
| CHEMBL1684625 | — | IC50 | = | 8250.0 | nM | 5.08 |
| CHEMBL1684631 | — | IC50 | = | 9010.0 | nM | 5.04 |
| CHEMBL1684619 | — | IC50 | = | 12360.0 | nM | 4.91 |
| CHEMBL1684620 | — | IC50 | = | 18880.0 | nM | 4.72 |
| CHEMBL1684626 | — | IC50 | = | 19750.0 | nM | 4.70 |
| CHEMBL1684630 | — | IC50 | = | 22210.0 | nM | 4.65 |
| CHEMBL1684618 | — | IC50 | = | 58240.0 | nM | 4.24 |
| CHEMBL1684621 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1684624 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1684632 | — | IC50 | > | 100000.0 | nM | - |