Assay Detail
Binding
CHEMBL1687315
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of STAT3 dimerization in mouse NIH3T3 cells expressing v-Src assessed as disruption of STAT3-STAT3: DNA complexation in nucleus after 30 mins by electrophoretic mobility shift assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL5402) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.35 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1681824 | — | — | 1 | 5.30 |
| CHEMBL1684873 | — | — | 1 | 4.48 |
| CHEMBL1684879 | — | — | 1 | 4.40 |
| CHEMBL1681825 | — | — | 1 | 4.22 |
| CHEMBL1684877 | — | — | 1 | 4.21 |
| CHEMBL1684878 | — | — | 1 | 4.19 |
| CHEMBL1681829 | — | — | 1 | 4.18 |
| CHEMBL1684872 | — | — | 1 | 4.14 |
| CHEMBL1681828 | — | — | 1 | 4.04 |
| CHEMBL1684875 | — | — | 1 | - |
| CHEMBL1684876 | — | — | 1 | - |
| CHEMBL1681827 | — | — | 1 | - |
| CHEMBL1681826 | — | — | 1 | - |
| CHEMBL1684874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1681824 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1684873 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1684879 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1681825 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1684877 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL1684878 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1681829 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL1684872 | — | IC50 | = | 73100.0 | nM | 4.14 |
| CHEMBL1681828 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL1684875 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL1684876 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL1681827 | — | IC50 | = | 188000.0 | nM | - |
| CHEMBL1681826 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL1684874 | — | IC50 | > | 200000.0 | nM | - |