Assay Detail
Functional
CHEMBL1687491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse CXCR3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
II. SAR studies of pyridyl-piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.38 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472288 | — | — | 1 | 9.30 |
| CHEMBL1681882 | — | — | 1 | 8.96 |
| CHEMBL1681849 | — | — | 1 | 8.17 |
| CHEMBL1681848 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472288 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1681882 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1681849 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1681848 | — | IC50 | = | 84.0 | nM | 7.08 |