Assay Detail
Binding
CHEMBL1689851
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Inhibition of beta-lactamase SHV-4 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.69 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 8.52 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 8.40 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 7.26 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1689063 | AVIBACTAM | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL403 | SULBACTAM | IC50 | = | 260.0 | nM | 6.58 |