Assay Detail

CHEMBL1690218

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Binding

Inhibition of HIV1 HXB2 reverse transcriptase K103N mutant activity by primer extension assay

ChEMBL ↗

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Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗

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Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human immunodeficiency virus type 1 reverse transcriptase

CHEMBL247

Anchored from Assay target.

Protein identity Human immunodeficiency virus type 1 reverse transcriptase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Human immunodeficiency virus 1
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗

Type	SINGLE PROTEIN
Organism	Human immunodeficiency virus 1

Publication

Lersivirine, a nonnucleoside reverse transcriptase inhibitor with activity against drug-resistant human immunodeficiency virus type 1.

Corbau R, Mori J, Phillips C, Fishburn L, Martin A, Mowbray C, Panton W, Smith-Burchnell C, Thornberry A, Ringrose H, Knöchel T, Irving S, Westby M, Wood A, Perros M.
Antimicrob Agents Chemother (2010) 54 : 4451 -4463
PubMed 20660667 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.53	6.67

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL571987	LERSIVIRINE	2.0	1	6.67
CHEMBL223228	EFAVIRENZ	4.0	1	6.38

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL571987	LERSIVIRINE	IC50	=	215.0	nM	6.67
CHEMBL223228	EFAVIRENZ	IC50	=	414.0	nM	6.38