Assay Detail
Functional
CHEMBL1692902
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Cytotoxicity against human SMMC7721 cells for 72 hrs under hypoxic condition by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.71 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1689497 | — | — | 1 | 6.28 |
| CHEMBL1689499 | — | — | 1 | 6.26 |
| CHEMBL1689501 | — | — | 1 | 6.13 |
| CHEMBL1689496 | — | — | 1 | 6.11 |
| CHEMBL1689493 | — | — | 1 | 6.09 |
| CHEMBL1689498 | — | — | 1 | 5.97 |
| CHEMBL1689495 | — | — | 1 | 5.94 |
| CHEMBL1689500 | — | — | 1 | 5.92 |
| CHEMBL1689494 | — | — | 1 | 5.61 |
| CHEMBL1689484 | — | — | 1 | 5.61 |
| CHEMBL1689489 | — | — | 1 | 5.54 |
| CHEMBL1689488 | — | — | 1 | 5.52 |
| CHEMBL1689491 | — | — | 1 | 5.51 |
| CHEMBL1689487 | — | — | 1 | 5.40 |
| CHEMBL1689490 | — | — | 1 | 5.38 |
| CHEMBL1689485 | — | — | 1 | 5.37 |
| CHEMBL1689492 | — | — | 1 | 5.32 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.32 |
| CHEMBL1689486 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1689497 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1689499 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1689501 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1689496 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1689493 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1689498 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL1689495 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL1689500 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL1689494 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL1689484 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL1689489 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL1689488 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL1689491 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL1689487 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL1689490 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL1689485 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL1689492 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL1689486 | — | IC50 | = | 5530.0 | nM | 5.26 |