Assay Detail
Binding
CHEMBL1693159
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Displacement of wild type mBimBH3 from human Bcl-w by solution competition assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.64 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 7.40 |
| CHEMBL1689141 | — | — | 1 | 6.61 |
| CHEMBL1689145 | — | — | 1 | 6.56 |
| CHEMBL1689139 | — | — | 1 | 6.36 |
| CHEMBL1689143 | — | — | 1 | 6.27 |
| CHEMBL1689140 | — | — | 1 | - |
| CHEMBL1689142 | — | — | 1 | - |
| CHEMBL1689144 | — | — | 1 | - |
| CHEMBL1689146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1689141 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL1689145 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL1689139 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1689143 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1689140 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1689142 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1689144 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1689146 | — | IC50 | > | 1000.0 | nM | - |