Assay Detail
Binding
CHEMBL1694074
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental microsome CYP19 using [1beta-3H] androstenedione as a substrate
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.68 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688911 | — | — | 1 | 7.33 |
| CHEMBL437731 | — | — | 1 | 7.29 |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 7.28 |
| CHEMBL1688915 | — | — | 1 | 7.17 |
| CHEMBL1688910 | — | — | 1 | 7.16 |
| CHEMBL1688903 | — | — | 1 | 7.14 |
| CHEMBL1688902 | — | — | 1 | 7.14 |
| CHEMBL1688909 | — | — | 1 | 7.09 |
| CHEMBL1688912 | — | — | 1 | 6.98 |
| CHEMBL1688891 | — | — | 1 | 6.95 |
| CHEMBL1688906 | — | — | 1 | 6.95 |
| CHEMBL1688893 | — | — | 1 | 6.94 |
| CHEMBL1688898 | — | — | 1 | 6.90 |
| CHEMBL1688890 | — | — | 1 | 6.89 |
| CHEMBL1688895 | — | — | 1 | 6.85 |
| CHEMBL225499 | — | — | 1 | 6.82 |
| CHEMBL1688907 | — | — | 1 | 6.79 |
| CHEMBL1688901 | — | — | 1 | 6.78 |
| CHEMBL1688900 | — | — | 1 | 6.77 |
| CHEMBL1688897 | — | — | 1 | 6.75 |
| CHEMBL1688894 | — | — | 1 | 6.68 |
| CHEMBL1688892 | — | — | 1 | 6.63 |
| CHEMBL1688896 | — | — | 1 | 6.57 |
| CHEMBL225472 | — | — | 1 | 6.55 |
| CHEMBL1688904 | — | — | 1 | 6.54 |
| CHEMBL1688908 | — | — | 1 | 6.53 |
| CHEMBL1688916 | — | — | 1 | 6.50 |
| CHEMBL1688919 | — | — | 1 | 6.50 |
| CHEMBL1688914 | — | — | 1 | 6.34 |
| CHEMBL1688899 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688911 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL437731 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1688915 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1688910 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1688903 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1688902 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1688909 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1688912 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL1688891 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1688906 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1688893 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL1688898 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL1688890 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1688895 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL225499 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1688907 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1688901 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1688900 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL1688897 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL1688894 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL1688892 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL1688896 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL225472 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1688904 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL1688908 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL1688916 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL1688919 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL1688914 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL1688899 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL1688917 | — | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL1688905 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL387892 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL1688913 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL1688918 | — | IC50 | = | 4010.0 | nM | 5.40 |