Assay Detail
Binding
CHEMBL1694080
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Inhibition of C-terminal His6-tagged human Eg5 basal ATPase activity
25
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.33 | 7.14 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 7.14 |
| CHEMBL1688930 | — | — | 1 | 7.12 |
| CHEMBL1688927 | — | — | 1 | 7.08 |
| CHEMBL399251 | — | — | 1 | 7.01 |
| CHEMBL408072 | — | — | 1 | 6.81 |
| CHEMBL259257 | — | — | 1 | 6.76 |
| CHEMBL1688931 | — | — | 1 | 6.52 |
| CHEMBL1688926 | — | — | 1 | 6.37 |
| CHEMBL1688925 | — | — | 1 | 5.87 |
| CHEMBL1688929 | — | — | 1 | 5.60 |
| CHEMBL1688924 | — | — | 1 | 5.49 |
| CHEMBL1688932 | — | — | 1 | 4.23 |
| CHEMBL1688923 | — | — | 1 | - |
| CHEMBL1688922 | — | — | 1 | - |
| CHEMBL232133 | — | — | 1 | - |
| CHEMBL1688921 | — | — | 1 | - |
| CHEMBL1688920 | — | — | 1 | - |
| CHEMBL1688928 | — | — | 1 | - |
| CHEMBL412132 | — | — | 1 | - |
| CHEMBL409102 | — | — | 1 | - |
| CHEMBL429597 | — | — | 1 | - |
| CHEMBL259256 | — | — | 1 | - |
| CHEMBL261613 | — | — | 1 | - |
| CHEMBL1688933 | — | — | 1 | - |
| CHEMBL392369 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | Ki | = | 71.9 | nM | 7.14 |
| CHEMBL1688930 | — | Ki | = | 76.2 | nM | 7.12 |
| CHEMBL1688927 | — | Ki | = | 84.2 | nM | 7.08 |
| CHEMBL399251 | — | Ki | = | 98.6 | nM | 7.01 |
| CHEMBL408072 | — | Ki | = | 156.1 | nM | 6.81 |
| CHEMBL259257 | — | Ki | = | 174.5 | nM | 6.76 |
| CHEMBL1688931 | — | Ki | = | 302.1 | nM | 6.52 |
| CHEMBL1688926 | — | Ki | = | 428.6 | nM | 6.37 |
| CHEMBL1688925 | — | Ki | = | 1349.7 | nM | 5.87 |
| CHEMBL1688929 | — | Ki | = | 2536.3 | nM | 5.60 |
| CHEMBL1688924 | — | Ki | = | 3263.7 | nM | 5.49 |
| CHEMBL1688932 | — | Ki | = | 58333.0 | nM | 4.23 |
| CHEMBL1688923 | — | Ki | < | 50.0 | nM | - |
| CHEMBL1688922 | — | Ki | < | 50.0 | nM | - |
| CHEMBL232133 | — | Ki | < | 50.0 | nM | - |
| CHEMBL1688921 | — | Ki | < | 50.0 | nM | - |
| CHEMBL1688920 | — | Ki | < | 50.0 | nM | - |
| CHEMBL1688928 | — | Ki | < | 50.0 | nM | - |
| CHEMBL412132 | — | Ki | < | 50.0 | nM | - |
| CHEMBL409102 | — | Ki | < | 50.0 | nM | - |
| CHEMBL429597 | — | Ki | < | 50.0 | nM | - |
| CHEMBL259256 | — | Ki | < | 50.0 | nM | - |
| CHEMBL261613 | — | Ki | < | 50.0 | nM | - |
| CHEMBL1688933 | — | Inhibition | - | % | - | |
| CHEMBL392369 | — | Ki | < | 50.0 | nM | - |