Assay Detail
Binding
CHEMBL1694677
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Inhibition of Plasmodium falciparum thioredoxin reductase TrxR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Compounds structurally related to ellagic acid show improved antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.67 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688544 | CORULEOELLAGIC ACID | — | 1 | 5.17 |
| CHEMBL1688543 | FLAVELLAGIC ACID | — | 1 | 4.66 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688544 | CORULEOELLAGIC ACID | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1688543 | FLAVELLAGIC ACID | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 66700.0 | nM | 4.18 |