Assay Detail
Functional
CHEMBL1694682
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum HB3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Compounds structurally related to ellagic acid show improved antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.92 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.80 |
| CHEMBL1688544 | CORULEOELLAGIC ACID | — | 1 | 7.14 |
| CHEMBL1688543 | FLAVELLAGIC ACID | — | 1 | 6.86 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1688544 | CORULEOELLAGIC ACID | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1688543 | FLAVELLAGIC ACID | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 1325.0 | nM | 5.88 |