Assay Detail
Binding
CHEMBL1695104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis recombinant Rv1284 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-carbonic anhydrase 1 (CHEMBL5631) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.56 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.32 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.21 |
| CHEMBL463134 | (+)-XYLARIAMIDE A | — | 1 | 6.15 |
| CHEMBL601464 | — | — | 1 | 6.10 |
| CHEMBL517222 | ENDIANDRIN B | — | 1 | 6.10 |
| CHEMBL228274 | ENDIANDRIN A | — | 1 | 6.09 |
| CHEMBL463133 | (-)-XYLARIAMIDE A | — | 1 | 6.08 |
| CHEMBL53566 | TYROSOL | — | 1 | 6.07 |
| CHEMBL447310 | — | — | 1 | 6.07 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | — | 1 | 6.07 |
| CHEMBL591736 | POLYANDROCARPAMINE B | — | 1 | 6.04 |
| CHEMBL590883 | — | — | 1 | 6.00 |
| CHEMBL606453 | — | — | 1 | 5.94 |
| CHEMBL589606 | — | — | 1 | 5.90 |
| CHEMBL589604 | — | — | 1 | 5.75 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 5.01 |
| CHEMBL592010 | — | — | 1 | 4.99 |
| CHEMBL592384 | — | — | 1 | 4.98 |
| CHEMBL592140 | — | — | 1 | 4.98 |
| CHEMBL1772 | — | — | 1 | 4.97 |
| CHEMBL588491 | — | — | 1 | 4.96 |
| CHEMBL605189 | — | — | 1 | 4.94 |
| CHEMBL603189 | POLYANDROCARPAMINE A | — | 1 | 4.93 |
| CHEMBL578932 | — | — | 1 | 4.91 |
| CHEMBL589354 | — | — | 1 | 4.91 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 4.19 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL463134 | (+)-XYLARIAMIDE A | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL601464 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL517222 | ENDIANDRIN B | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL228274 | ENDIANDRIN A | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL463133 | (-)-XYLARIAMIDE A | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL53566 | TYROSOL | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL447310 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL591736 | POLYANDROCARPAMINE B | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL590883 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL606453 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL589606 | — | Ki | = | 1270.0 | nM | 5.90 |
| CHEMBL589604 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 9840.0 | nM | 5.01 |
| CHEMBL592010 | — | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL592384 | — | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL592140 | — | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL1772 | — | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL588491 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL605189 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL603189 | POLYANDROCARPAMINE A | Ki | = | 11800.0 | nM | 4.93 |
| CHEMBL578932 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL589354 | — | Ki | = | 12200.0 | nM | 4.91 |
| CHEMBL14060 | PHENOL | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 286800.0 | nM | - |