Assay Detail
Binding
CHEMBL1696017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells at 10 uM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.78 | 8.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387921 | — | — | 1 | 8.78 |
| CHEMBL1688378 | — | — | 1 | 7.93 |
| CHEMBL1688379 | — | — | 1 | 7.88 |
| CHEMBL1688380 | — | — | 1 | 7.70 |
| CHEMBL1688381 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387921 | — | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL1688378 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL1688379 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL1688380 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1688381 | — | Ki | = | 259.0 | nM | 6.59 |