Assay Detail
Binding
CHEMBL1696289
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Inhibition of Cyclophilin 18 PPIase activity
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase A (CHEMBL1949) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Facile synthesis of a fluorescent cyclosporin a analogue to study cyclophilin 40 and cyclophilin 18 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.81 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688203 | — | — | 1 | 6.97 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688203 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL160 | CYCLOSPORINE | Ki | = | 227.0 | nM | 6.64 |