Assay Detail
Binding
CHEMBL1696362
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Inhibition of HIV1 Rev expressed in african green monkey 5BD.1 cells assessed as inhibition of p24 antigen treated for 16 hrs after washout with medium again readded for 8 hrs by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.51 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688538 | — | — | 1 | 6.70 |
| CHEMBL1688535 | — | — | 1 | 6.05 |
| CHEMBL1688537 | — | — | 1 | 6.05 |
| CHEMBL1688536 | — | — | 1 | 5.72 |
| CHEMBL226970 | — | — | 1 | 5.60 |
| CHEMBL1688534 | — | — | 1 | 5.52 |
| CHEMBL1688539 | — | — | 1 | 5.52 |
| CHEMBL1423945 | — | — | 1 | 5.31 |
| CHEMBL1688531 | — | — | 1 | 5.00 |
| CHEMBL1688532 | — | — | 1 | 4.66 |
| CHEMBL1688533 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688538 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1688535 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1688537 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1688536 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL226970 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1688534 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1688539 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1423945 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1688531 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1688532 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1688533 | — | EC50 | = | 30000.0 | nM | 4.52 |