Assay Detail
Binding
CHEMBL1696365
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Inhibition of HIV1 Rev expressed in human HeLa cells co-expressing renilla luciferase reporter gene assessed as inhibition of renilla luciferase expression after 24 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.58 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486133 | LEPTOMYCIN B | — | 1 | 8.09 |
| CHEMBL1688535 | — | — | 1 | 6.32 |
| CHEMBL1688537 | — | — | 1 | 5.97 |
| CHEMBL226970 | — | — | 1 | 5.65 |
| CHEMBL1688534 | — | — | 1 | 5.62 |
| CHEMBL1688538 | — | — | 1 | 5.13 |
| CHEMBL1423945 | — | — | 1 | 5.10 |
| CHEMBL1688531 | — | — | 1 | 5.05 |
| CHEMBL1688539 | — | — | 1 | 5.05 |
| CHEMBL1688536 | — | — | 1 | 5.01 |
| CHEMBL1688533 | — | — | 1 | 4.96 |
| CHEMBL1688532 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486133 | LEPTOMYCIN B | EC50 | = | 8.22 | nM | 8.09 |
| CHEMBL1688535 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1688537 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL226970 | — | EC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL1688534 | — | EC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL1688538 | — | EC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL1423945 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1688531 | — | EC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL1688539 | — | EC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL1688536 | — | EC50 | = | 9730.0 | nM | 5.01 |
| CHEMBL1688533 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1688532 | — | EC50 | = | 11200.0 | nM | 4.95 |