Assay Detail
Functional
CHEMBL1696986
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Antimicrobial activity against wild type Leishmania donovani AG83 assessed as inhibition of parasite growth after 24 hrs by MTT assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| IC50 | 1 | 5.90 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446452 | ARUNDINE | 3.0 | 2 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446452 | ARUNDINE | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL446452 | ARUNDINE | Inhibition | - | % | - |