Assay Detail

CHEMBL1697633

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to Leishmania donovani large subunit of topoisomerase 1b

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Loading context

Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Leishmania donovani
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane.

Roy A, BoseDasgupta S, Ganguly A, Jaisankar P, Majumder HK.
Antimicrob Agents Chemother (2009) 53 : 2589 -2598
PubMed 19332675 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	6.37	6.37

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL446452	ARUNDINE	3.0	1	6.37

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL446452	ARUNDINE	Kd	=	428.0	nM	6.37