Assay Detail
Functional
CHEMBL1738313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Dose Response confirmation of activators of hexokinase domain containing I (HKDC1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493187, AID493207]
104
Total Activities
104
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 104 | 4.83 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1713955 | — | — | 1 | 6.67 |
| CHEMBL1725990 | — | — | 1 | 6.21 |
| CHEMBL1708020 | — | — | 1 | 5.79 |
| CHEMBL1702026 | — | — | 1 | 5.75 |
| CHEMBL1705535 | — | — | 1 | 5.74 |
| CHEMBL169811 | — | — | 1 | 5.66 |
| CHEMBL1329129 | — | — | 1 | 5.66 |
| CHEMBL1401989 | — | — | 1 | 5.65 |
| CHEMBL1701797 | — | — | 1 | 5.65 |
| CHEMBL1709153 | — | — | 1 | 5.64 |
| CHEMBL1717079 | — | — | 1 | 5.52 |
| CHEMBL1550584 | — | — | 1 | 5.44 |
| CHEMBL1578997 | — | — | 1 | 5.25 |
| CHEMBL1414923 | — | — | 1 | 5.18 |
| CHEMBL3145303 | — | — | 1 | 5.17 |
| CHEMBL1470212 | — | — | 1 | 5.12 |
| CHEMBL1576392 | — | — | 1 | 5.10 |
| CHEMBL1706082 | — | — | 1 | 5.09 |
| CHEMBL1312377 | — | — | 1 | 5.08 |
| CHEMBL1478479 | — | — | 1 | 5.06 |
| CHEMBL1704311 | — | — | 1 | 5.04 |
| CHEMBL1308783 | — | — | 1 | 5.03 |
| CHEMBL1589350 | — | — | 1 | 5.00 |
| CHEMBL1461738 | — | — | 1 | 4.99 |
| CHEMBL1482926 | — | — | 1 | 4.96 |
| CHEMBL1557023 | — | — | 1 | 4.94 |
| CHEMBL1558692 | — | — | 1 | 4.93 |
| CHEMBL600862 | — | — | 1 | 4.88 |
| CHEMBL1733942 | — | — | 1 | 4.88 |
| CHEMBL1322745 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1713955 | — | EC50 | = | 212.0 | nM | 6.67 |
| CHEMBL1725990 | — | EC50 | = | 615.0 | nM | 6.21 |
| CHEMBL1708020 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL1702026 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL1705535 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL1329129 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL169811 | — | EC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL1401989 | — | EC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL1701797 | — | EC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL1709153 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL1717079 | — | EC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL1550584 | — | EC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL1578997 | — | EC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL1414923 | — | EC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL3145303 | — | EC50 | = | 6690.0 | nM | 5.17 |
| CHEMBL1470212 | — | EC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL1576392 | — | EC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL1706082 | — | EC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL1312377 | — | EC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL1478479 | — | EC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL1704311 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL1308783 | — | EC50 | = | 9250.0 | nM | 5.03 |
| CHEMBL1589350 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1461738 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL1482926 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL1557023 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1558692 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL600862 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL1733942 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL1322745 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL1790033 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL1708343 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1528481 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1706392 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1454194 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1976317 | — | EC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL1382826 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1345979 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1516663 | — | EC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL1344977 | — | EC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL1432378 | — | EC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL1299995 | — | EC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL1501771 | — | EC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL3199665 | — | EC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL1559226 | — | EC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL263972 | — | EC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL1375373 | — | EC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL1339349 | — | EC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL1417967 | — | EC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL1582527 | — | EC50 | = | 23900.0 | nM | 4.62 |