Assay Detail
Binding
CHEMBL1763070
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Inhibition of NET
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.06 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762472 | — | — | 1 | 6.30 |
| CHEMBL1762478 | — | — | 1 | 5.15 |
| CHEMBL1762480 | — | — | 1 | 5.13 |
| CHEMBL1762476 | — | — | 1 | 4.92 |
| CHEMBL1762473 | — | — | 1 | 4.82 |
| CHEMBL1762479 | — | — | 1 | 4.80 |
| CHEMBL1762474 | — | — | 1 | 4.77 |
| CHEMBL1762475 | — | — | 1 | 4.55 |
| CHEMBL447183 | — | — | 1 | - |
| CHEMBL1762470 | — | — | 1 | - |
| CHEMBL1762471 | — | — | 1 | - |
| CHEMBL1762477 | — | — | 1 | - |
| CHEMBL1762481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762472 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1762478 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL1762480 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1762476 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1762473 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1762479 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1762474 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1762475 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL447183 | — | IC50 | - | — | - | |
| CHEMBL1762470 | — | IC50 | - | — | - | |
| CHEMBL1762471 | — | IC50 | = | - | nM | - |
| CHEMBL1762477 | — | IC50 | - | — | - | |
| CHEMBL1762481 | — | IC50 | > | 100000.0 | nM | - |