Assay Detail
Functional
CHEMBL1763084
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Cytostatic activity against mouse FM3A cells after 2 days by coulter counting analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FM3A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.92 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 8.03 |
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | 7.85 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.75 |
| CHEMBL1762220 | — | — | 1 | 6.64 |
| CHEMBL1762230 | — | — | 1 | 5.72 |
| CHEMBL1762225 | — | — | 1 | 5.62 |
| CHEMBL1762222 | — | — | 1 | 4.34 |
| CHEMBL1762221 | — | — | 1 | 4.21 |
| CHEMBL1762218 | — | — | 1 | 4.11 |
| CHEMBL1762219 | — | — | 1 | - |
| CHEMBL1762223 | — | — | 1 | - |
| CHEMBL1762224 | — | — | 1 | - |
| CHEMBL1762226 | — | — | 1 | - |
| CHEMBL1762227 | — | — | 1 | - |
| CHEMBL1762228 | — | — | 1 | - |
| CHEMBL1762229 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL54918 | 5-FLUOROURIDINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1762220 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1762230 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1762225 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1762222 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1762221 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL1762218 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL1762219 | — | IC50 | = | 121000.0 | nM | - |
| CHEMBL1762223 | — | IC50 | >= | 900000.0 | nM | - |
| CHEMBL1762224 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1762226 | — | IC50 | = | 379000.0 | nM | - |
| CHEMBL1762227 | — | IC50 | >= | 1800000.0 | nM | - |
| CHEMBL1762228 | — | IC50 | = | 775000.0 | nM | - |
| CHEMBL1762229 | — | IC50 | > | 800000.0 | nM | - |