Assay Detail
Functional
CHEMBL1763086
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Cytostatic activity against human HeLa cells after 3 days by coulter counting analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.00 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.35 |
| CHEMBL1762220 | — | — | 1 | 6.01 |
| CHEMBL1762225 | — | — | 1 | 5.46 |
| CHEMBL1762230 | — | — | 1 | 4.75 |
| CHEMBL1762218 | — | — | 1 | 4.47 |
| CHEMBL1762222 | — | — | 1 | 4.47 |
| CHEMBL1762219 | — | — | 1 | 4.38 |
| CHEMBL1762221 | — | — | 1 | 4.14 |
| CHEMBL1762223 | — | — | 1 | - |
| CHEMBL1762224 | — | — | 1 | - |
| CHEMBL1762226 | — | — | 1 | - |
| CHEMBL1762227 | — | — | 1 | - |
| CHEMBL1762228 | — | — | 1 | - |
| CHEMBL1762229 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1762220 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1762225 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1762230 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1762218 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1762222 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1762219 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1762221 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1762223 | — | IC50 | = | 339000.0 | nM | - |
| CHEMBL1762224 | — | IC50 | = | 760000.0 | nM | - |
| CHEMBL1762226 | — | IC50 | = | 296000.0 | nM | - |
| CHEMBL1762227 | — | IC50 | = | 990000.0 | nM | - |
| CHEMBL1762228 | — | IC50 | >= | 800000.0 | nM | - |
| CHEMBL1762229 | — | IC50 | >= | 800000.0 | nM | - |