Assay Detail
Functional
CHEMBL1763090
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Cytostatic activity against mouse L1210 cells in presence of 500 uM uracil
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.61 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 9.20 |
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | 8.12 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.33 |
| CHEMBL1762220 | — | — | 1 | 6.00 |
| CHEMBL1762225 | — | — | 1 | 5.24 |
| CHEMBL1762230 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL54918 | 5-FLUOROURIDINE | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1762220 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1762225 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1762230 | — | IC50 | = | 18000.0 | nM | 4.75 |