Assay Detail
Functional
CHEMBL1763092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytostatic activity against human HeLa cells in presence of 20 uM 2'-deoxyuridine
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.51 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 7.68 |
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | 7.66 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.75 |
| CHEMBL1762220 | — | — | 1 | 6.21 |
| CHEMBL1762225 | — | — | 1 | 5.85 |
| CHEMBL1762230 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL54918 | 5-FLUOROURIDINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1762220 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1762225 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1762230 | — | IC50 | = | 12000.0 | nM | 4.92 |