Assay Detail
Functional
CHEMBL1763096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DNA synthesis in mouse L1210 cells assessed as [6-3H]2'-deoxyuridine incorporation in to DNA by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.01 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.01 |
| CHEMBL1762220 | — | — | 1 | 5.51 |
| CHEMBL1762225 | — | — | 1 | 4.43 |
| CHEMBL1762230 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1762220 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1762225 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1762230 | — | IC50 | = | 85000.0 | nM | 4.07 |