Assay Detail
Functional
CHEMBL1763100
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Inhibition of RNA synthesis in mouse L1210 cells assessed as [5-3H]uridine incorporation in to RNA preincubated for 24 hrs by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.73 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.31 |
| CHEMBL1762220 | — | — | 1 | 4.80 |
| CHEMBL1762225 | — | — | 1 | 4.08 |
| CHEMBL1762230 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1762220 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1762225 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL1762230 | — | IC50 | = | 282000.0 | nM | - |