Assay Detail
Binding
CHEMBL1763187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SGLT6 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium/myo-inositol cotransporter 2 (CHEMBL1744524) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of non-glucoside SGLT2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.43 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 6.42 |
| CHEMBL1762505 | — | — | 1 | 5.04 |
| CHEMBL1762504 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429910 | DAPAGLIFLOZIN | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1762505 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1762504 | — | IC50 | = | 14400.0 | nM | 4.84 |