Assay Detail
Binding
CHEMBL1763188
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Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation counting in presence of 100% plasma
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of non-glucoside SGLT2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.59 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762505 | — | — | 1 | 7.72 |
| CHEMBL429910 | DAPAGLIFLOZIN | 4.0 | 1 | 7.66 |
| CHEMBL1762504 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762505 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL429910 | DAPAGLIFLOZIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1762504 | — | IC50 | = | 40.0 | nM | 7.40 |