Assay Detail
Binding
CHEMBL1763239
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Inhibition of Bcr/Abl by FRET-based Z-lyte assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Hybrid compounds as new Bcr/Abl inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.36 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760371 | — | — | 1 | 7.70 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 7.41 |
| CHEMBL1760370 | — | — | 1 | 6.75 |
| CHEMBL1760367 | — | — | 1 | 6.56 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.51 |
| CHEMBL1760365 | — | — | 1 | 6.32 |
| CHEMBL1760366 | — | — | 1 | 6.31 |
| CHEMBL1760364 | — | — | 1 | 6.29 |
| CHEMBL1760363 | — | — | 1 | 6.17 |
| CHEMBL1760369 | — | — | 1 | 6.11 |
| CHEMBL1760373 | — | — | 1 | 5.89 |
| CHEMBL1760374 | — | — | 1 | 5.42 |
| CHEMBL1760375 | — | — | 1 | 5.26 |
| CHEMBL1760368 | — | — | 1 | - |
| CHEMBL1760372 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760371 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 39.3 | nM | 7.41 |
| CHEMBL1760370 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL1760367 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL941 | IMATINIB | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL1760365 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1760366 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL1760364 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL1760363 | — | IC50 | = | 671.0 | nM | 6.17 |
| CHEMBL1760369 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL1760373 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1760374 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL1760375 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL1760368 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1760372 | — | IC50 | > | 2000.0 | nM | - |