Assay Detail
Functional
CHEMBL1763242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human imatinib-resistant K562 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrid compounds as new Bcr/Abl inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.84 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 1 | 8.22 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 6.58 |
| CHEMBL1760371 | — | — | 1 | 6.19 |
| CHEMBL1760368 | — | — | 1 | 5.84 |
| CHEMBL1760365 | — | — | 1 | 5.79 |
| CHEMBL1760374 | — | — | 1 | 5.76 |
| CHEMBL1760363 | — | — | 1 | 5.74 |
| CHEMBL1760364 | — | — | 1 | 5.67 |
| CHEMBL1760373 | — | — | 1 | 5.63 |
| CHEMBL1760375 | — | — | 1 | 5.57 |
| CHEMBL1760370 | — | — | 1 | 5.54 |
| CHEMBL1760369 | — | — | 1 | 5.48 |
| CHEMBL1760367 | — | — | 1 | 5.46 |
| CHEMBL1760366 | — | — | 1 | 5.27 |
| CHEMBL1760372 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 6.05 | nM | 8.22 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1760371 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1760368 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL1760365 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL1760374 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL1760363 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL1760364 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL1760373 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL1760375 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL1760370 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL1760369 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL1760367 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL1760366 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL1760372 | — | IC50 | = | 11850.0 | nM | 4.93 |