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Assay Detail

CHEMBL1763285

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of muscle nAChR
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Muscle tissue
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.
Zheng G, Zhang Z, Dowell C, Wala E, Dwoskin LP, Holtman JR, McIntosh JM, Crooks PA.
Bioorg Med Chem Lett (2011) 21 : 2476 -2479
PubMed 21397497 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.92 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL451442 1 6.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL451442 IC50 = 120.0 nM 6.92