Assay Detail
Functional
CHEMBL1763455
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Cytotoxicity against human MCF7 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.91 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762765 | — | — | 1 | 5.17 |
| CHEMBL1762764 | ARMILLARIDIN | — | 1 | 5.11 |
| CHEMBL1762770 | DEHYDROARMILLYLORSELLINATE | — | 1 | 5.10 |
| CHEMBL1762773 | ARMILLARIN | — | 1 | 4.94 |
| CHEMBL1078389 | ARNAMIAL | — | 1 | 4.81 |
| CHEMBL1762767 | — | — | 1 | 4.67 |
| CHEMBL1762766 | — | — | 1 | 4.58 |
| CHEMBL1762772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762765 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1762764 | ARMILLARIDIN | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1762770 | DEHYDROARMILLYLORSELLINATE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1762773 | ARMILLARIN | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL1078389 | ARNAMIAL | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1762767 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL1762766 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL1762772 | — | IC50 | > | 100000.0 | nM | - |