Assay Detail
Functional
CHEMBL1763457
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HeLa cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.70 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762764 | ARMILLARIDIN | — | 1 | 5.04 |
| CHEMBL1762770 | DEHYDROARMILLYLORSELLINATE | — | 1 | 4.82 |
| CHEMBL1762773 | ARMILLARIN | — | 1 | 4.78 |
| CHEMBL1762765 | — | — | 1 | 4.73 |
| CHEMBL1762766 | — | — | 1 | 4.45 |
| CHEMBL1762767 | — | — | 1 | 4.40 |
| CHEMBL1078389 | ARNAMIAL | — | 1 | - |
| CHEMBL1762772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762764 | ARMILLARIDIN | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1762770 | DEHYDROARMILLYLORSELLINATE | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL1762773 | ARMILLARIN | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL1762765 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL1762766 | — | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL1762767 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1078389 | ARNAMIAL | IC50 | - | — | - | |
| CHEMBL1762772 | — | IC50 | > | 100000.0 | nM | - |