Assay Detail
Functional
CHEMBL1763458
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Cytotoxicity against human K562 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.84 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762770 | DEHYDROARMILLYLORSELLINATE | — | 1 | 5.30 |
| CHEMBL1762764 | ARMILLARIDIN | — | 1 | 5.05 |
| CHEMBL1762773 | ARMILLARIN | — | 1 | 5.00 |
| CHEMBL1762765 | — | — | 1 | 4.69 |
| CHEMBL1762766 | — | — | 1 | 4.60 |
| CHEMBL1762767 | — | — | 1 | 4.41 |
| CHEMBL1078389 | ARNAMIAL | — | 1 | - |
| CHEMBL1762772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762770 | DEHYDROARMILLYLORSELLINATE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1762764 | ARMILLARIDIN | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1762773 | ARMILLARIN | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1762765 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL1762766 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1762767 | — | IC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL1078389 | ARNAMIAL | IC50 | - | — | - | |
| CHEMBL1762772 | — | IC50 | > | 100000.0 | nM | - |