Assay Detail
Binding
CHEMBL1763480
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Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.87 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762790 | — | — | 1 | 9.70 |
| CHEMBL1760154 | — | — | 1 | 8.70 |
| CHEMBL1762788 | — | — | 1 | 8.15 |
| CHEMBL1762782 | — | — | 1 | 8.10 |
| CHEMBL1760155 | — | — | 1 | 7.89 |
| CHEMBL1762778 | — | — | 1 | 7.68 |
| CHEMBL1760172 | — | — | 1 | 7.62 |
| CHEMBL1760158 | — | — | 1 | 7.57 |
| CHEMBL1615183 | — | — | 1 | 7.57 |
| CHEMBL1760157 | — | — | 1 | 7.55 |
| CHEMBL1760169 | — | — | 1 | 7.51 |
| CHEMBL1760170 | — | — | 1 | 7.22 |
| CHEMBL1760162 | — | — | 1 | 7.22 |
| CHEMBL1760171 | — | — | 1 | 7.10 |
| CHEMBL1760168 | — | — | 1 | 7.09 |
| CHEMBL1762785 | — | — | 1 | 7.06 |
| CHEMBL1615182 | — | — | 1 | 7.01 |
| CHEMBL1762781 | — | — | 1 | 6.96 |
| CHEMBL1760161 | — | — | 1 | 6.82 |
| CHEMBL1760165 | — | — | 1 | 6.82 |
| CHEMBL1760153 | — | — | 1 | 6.76 |
| CHEMBL1760163 | — | — | 1 | 6.72 |
| CHEMBL1762775 | — | — | 1 | 6.60 |
| CHEMBL1760159 | — | — | 1 | 6.57 |
| CHEMBL1760156 | — | — | 1 | 6.54 |
| CHEMBL1760160 | — | — | 1 | 6.47 |
| CHEMBL1762786 | — | — | 1 | 6.43 |
| CHEMBL1762783 | — | — | 1 | 6.41 |
| CHEMBL1762789 | — | — | 1 | 6.38 |
| CHEMBL1762774 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762790 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1760154 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1762788 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1762782 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1760155 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1762778 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1760172 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1760158 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1615183 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1760157 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1760169 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1760170 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1760162 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1760171 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1760168 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL1762785 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1615182 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1762781 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1760165 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1760161 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1760153 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL1760163 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1762775 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1760159 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1760156 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1760160 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1762786 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1762783 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1762789 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1762774 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1762779 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1762784 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1762777 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1760167 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL1760166 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL1762776 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1762787 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1762780 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760164 | — | IC50 | > | 50000.0 | nM | - |