Assay Detail
Binding
CHEMBL1763481
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Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-87 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.85 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762790 | — | — | 1 | 7.01 |
| CHEMBL1762788 | — | — | 1 | 6.82 |
| CHEMBL1760154 | — | — | 1 | 6.47 |
| CHEMBL1760172 | — | — | 1 | 6.47 |
| CHEMBL1760155 | — | — | 1 | 6.47 |
| CHEMBL1762782 | — | — | 1 | 6.42 |
| CHEMBL1615183 | — | — | 1 | 6.41 |
| CHEMBL1760169 | — | — | 1 | 6.22 |
| CHEMBL1760168 | — | — | 1 | 6.22 |
| CHEMBL1762778 | — | — | 1 | 6.15 |
| CHEMBL1760157 | — | — | 1 | 6.02 |
| CHEMBL1762785 | — | — | 1 | 5.92 |
| CHEMBL1760170 | — | — | 1 | 5.89 |
| CHEMBL1760171 | — | — | 1 | 5.85 |
| CHEMBL1760156 | — | — | 1 | 5.82 |
| CHEMBL1760158 | — | — | 1 | 5.82 |
| CHEMBL1615182 | — | — | 1 | 5.77 |
| CHEMBL1762775 | — | — | 1 | 5.54 |
| CHEMBL1760161 | — | — | 1 | 5.48 |
| CHEMBL1762781 | — | — | 1 | 5.46 |
| CHEMBL1760153 | — | — | 1 | 5.41 |
| CHEMBL1760162 | — | — | 1 | 5.38 |
| CHEMBL1760159 | — | — | 1 | 5.28 |
| CHEMBL1760163 | — | — | 1 | 5.28 |
| CHEMBL1762783 | — | — | 1 | 5.20 |
| CHEMBL1760160 | — | — | 1 | 5.19 |
| CHEMBL1762786 | — | — | 1 | 5.05 |
| CHEMBL1762787 | — | — | 1 | 4.67 |
| CHEMBL1762774 | — | — | 1 | - |
| CHEMBL1760167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762790 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1762788 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1760172 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1760155 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1760154 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1762782 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1615183 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1760169 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1760168 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1762778 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1760157 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1762785 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1760170 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1760171 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1760158 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1760156 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1615182 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1762775 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1760161 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1762781 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1760153 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1760162 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1760159 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1760163 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1762783 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1760160 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1762786 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1762787 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL1762779 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762780 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762784 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762777 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762789 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762776 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1760164 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1760165 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1760166 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1760167 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1762774 | — | IC50 | > | 25000.0 | nM | - |