Assay Detail
Binding
CHEMBL1763544
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Displacement of [125I]echistatin from human integrin alpha5beta3 expressed in human A549 cells by binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Exploring new near-infrared fluorescent disulfide-based cyclic RGD peptide analogs for potential integrin-targeted optical imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.99 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411941 | CYCLORGDFV | — | 1 | 6.49 |
| CHEMBL1761774 | — | — | 1 | 6.14 |
| CHEMBL1761773 | — | — | 1 | 5.34 |
| CHEMBL1761777 | — | — | 1 | - |
| CHEMBL1761776 | — | — | 1 | - |
| CHEMBL1761775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411941 | CYCLORGDFV | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL1761774 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1761773 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1761777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761776 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761775 | — | IC50 | > | 10000.0 | nM | - |