Assay Detail
Binding
CHEMBL1763555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hr
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.15 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1761942 | — | — | 1 | 7.52 |
| CHEMBL1761939 | — | — | 1 | 7.40 |
| CHEMBL1761937 | — | — | 1 | 7.30 |
| CHEMBL1761941 | — | — | 1 | 7.30 |
| CHEMBL1277162 | — | — | 1 | 7.22 |
| CHEMBL1761940 | — | — | 1 | 7.22 |
| CHEMBL179603 | — | — | 1 | 7.16 |
| CHEMBL1761938 | — | — | 1 | 7.05 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.00 |
| CHEMBL1761936 | — | — | 1 | 6.40 |
| CHEMBL1761932 | — | — | 1 | 6.22 |
| CHEMBL1278149 | — | — | 1 | 6.22 |
| CHEMBL1277254 | — | — | 1 | 6.22 |
| CHEMBL1277253 | — | — | 1 | 6.22 |
| CHEMBL1761930 | — | — | 1 | 6.16 |
| CHEMBL205089 | — | — | 1 | 6.00 |
| CHEMBL1277620 | — | — | 1 | 5.78 |
| CHEMBL1761944 | — | — | 1 | 5.37 |
| CHEMBL1761933 | — | — | 1 | 5.29 |
| CHEMBL301018 | — | — | 1 | 5.28 |
| CHEMBL1761943 | — | — | 1 | 5.26 |
| CHEMBL1761931 | — | — | 1 | 5.25 |
| CHEMBL1761929 | — | — | 1 | 5.24 |
| CHEMBL1761934 | — | — | 1 | 5.21 |
| CHEMBL1278148 | — | — | 1 | 5.02 |
| CHEMBL98798 | — | — | 1 | 5.01 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.83 |
| CHEMBL1276893 | — | — | 1 | - |
| CHEMBL1276892 | — | — | 1 | - |
| CHEMBL1761935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1761942 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1761939 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1761941 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1761937 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1277162 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1761940 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL179603 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1761938 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1761936 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1278149 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1277253 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1277254 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1761932 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1761930 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL205089 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1277620 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL1761944 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1761933 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL301018 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1761943 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1761931 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1761929 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1761934 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1278148 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL98798 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL939 | GEFITINIB | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL29197 | — | IC50 | - | — | - | |
| CHEMBL1761945 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL447230 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1278056 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1278057 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761928 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1278235 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761935 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1276892 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1276893 | — | IC50 | > | 10000.0 | nM | - |