Assay Detail
Functional
CHEMBL1763557
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Antiproliferative activity against human HT-29 cells at 10 uM after 72 hrs by MTS assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.23 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1278148 | — | — | 1 | 5.39 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 5.38 |
| CHEMBL1278056 | — | — | 1 | 5.28 |
| CHEMBL301018 | — | — | 1 | 5.24 |
| CHEMBL1761933 | — | — | 1 | 5.24 |
| CHEMBL447230 | — | — | 1 | 5.21 |
| CHEMBL1761944 | — | — | 1 | 5.21 |
| CHEMBL1761940 | — | — | 1 | 5.11 |
| CHEMBL29197 | — | — | 1 | 5.00 |
| CHEMBL1278235 | — | — | 1 | - |
| CHEMBL1761935 | — | — | 1 | - |
| CHEMBL1761945 | — | — | 1 | - |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1278148 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1278056 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL301018 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1761933 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL447230 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1761944 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1761940 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL29197 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1278235 | — | IC50 | - | — | - | |
| CHEMBL1761935 | — | IC50 | - | — | - | |
| CHEMBL1761945 | — | IC50 | - | — | - | |
| CHEMBL939 | GEFITINIB | IC50 | - | — | - |