Assay Detail
Binding
CHEMBL1763565
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Inhibition of PI3Kgamma
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.55 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762790 | — | — | 1 | 8.30 |
| CHEMBL1762788 | — | — | 1 | 8.10 |
| CHEMBL1760154 | — | — | 1 | 7.89 |
| CHEMBL1760155 | — | — | 1 | 7.70 |
| CHEMBL1760165 | — | — | 1 | 7.58 |
| CHEMBL1760167 | — | — | 1 | 7.52 |
| CHEMBL1615182 | — | — | 1 | 7.00 |
| CHEMBL1760156 | — | — | 1 | 6.96 |
| CHEMBL1760162 | — | — | 1 | 6.72 |
| CHEMBL1760158 | — | — | 1 | 6.70 |
| CHEMBL1760172 | — | — | 1 | 6.60 |
| CHEMBL1615183 | — | — | 1 | 6.50 |
| CHEMBL1760157 | — | — | 1 | 6.47 |
| CHEMBL1762789 | — | — | 1 | 6.33 |
| CHEMBL1760153 | — | — | 1 | 6.32 |
| CHEMBL1760163 | — | — | 1 | 6.21 |
| CHEMBL1760160 | — | — | 1 | 6.07 |
| CHEMBL1760161 | — | — | 1 | 5.64 |
| CHEMBL1760164 | — | — | 1 | 5.64 |
| CHEMBL1760168 | — | — | 1 | 5.50 |
| CHEMBL1760169 | — | — | 1 | 5.44 |
| CHEMBL1760171 | — | — | 1 | 5.43 |
| CHEMBL1760159 | — | — | 1 | 5.39 |
| CHEMBL1760170 | — | — | 1 | 5.21 |
| CHEMBL1760166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762790 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1762788 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1760154 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1760155 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1760165 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1760167 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1615182 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1760156 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1760162 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1760158 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1760172 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1615183 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1760157 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1762789 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1760153 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1760163 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1760160 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL1760161 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1760164 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1760168 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1760169 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1760171 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1760159 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1760170 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1760166 | — | IC50 | - | — | - |