Assay Detail
Functional
CHEMBL1763646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at SNSR4 in human HEK293 cells by FLIPR assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mas-related G-protein coupled receptor member X1 (CHEMBL5850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.82 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762707 | — | — | 1 | 7.85 |
| CHEMBL1762698 | — | — | 1 | 7.70 |
| CHEMBL1762699 | — | — | 1 | 7.66 |
| CHEMBL1762700 | — | — | 1 | 7.62 |
| CHEMBL1762701 | — | — | 1 | 7.40 |
| CHEMBL1760000 | — | — | 1 | 7.11 |
| CHEMBL1762702 | — | — | 1 | 7.06 |
| CHEMBL1762705 | — | — | 1 | 6.97 |
| CHEMBL1762703 | — | — | 1 | 6.61 |
| CHEMBL1762704 | — | — | 1 | 6.53 |
| CHEMBL1762696 | — | — | 1 | 6.52 |
| CHEMBL1762706 | — | — | 1 | 6.48 |
| CHEMBL1762693 | — | — | 1 | 6.28 |
| CHEMBL1762695 | — | — | 1 | 6.19 |
| CHEMBL1762697 | — | — | 1 | 6.12 |
| CHEMBL1762694 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762707 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1762698 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1762699 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1762700 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1762701 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1760000 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1762702 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1762705 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL1762703 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL1762704 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL1762696 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL1762706 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1762693 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1762695 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1762697 | — | IC50 | = | 758.0 | nM | 6.12 |
| CHEMBL1762694 | — | IC50 | = | 8060.0 | nM | 5.09 |