Assay Detail
Functional
CHEMBL1763652
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Antiproliferative activity against human SMMC7721 cells after 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMMC-7721 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Studies on chemical modification and biology of a natural product, gambogic acid (III): determination of the essential pharmacophore for biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.02 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555017 | GAMBOGIC ACID | — | 1 | 5.50 |
| CHEMBL1762708 | — | — | 1 | 5.09 |
| CHEMBL1762712 | — | — | 1 | 4.98 |
| CHEMBL1762711 | — | — | 1 | 4.93 |
| CHEMBL1762710 | — | — | 1 | 4.91 |
| CHEMBL1762709 | — | — | 1 | 4.70 |
| CHEMBL1762713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555017 | GAMBOGIC ACID | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1762708 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL1762712 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1762711 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL1762710 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL1762709 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1762713 | — | IC50 | = | 147000.0 | nM | - |