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Assay Detail

CHEMBL1763704

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at Toll-like receptor 7
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Toll-like receptor 7 (CHEMBL5936)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.
Tran TD, Pryde DC, Jones P, Adam FM, Benson N, Bish G, Calo F, Ciaramella G, Dixon R, Duckworth J, Fox DN, Hay DA, Hitchin J, Horscroft N, Howard M, Gardner I, Jones HM, Laxton C, Parkinson T, Parsons G, Proctor K, Smith MC, Smith N, Thomas A.
Bioorg Med Chem Lett (2011) 21 : 2389 -2393
PubMed 21419626 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 6.68 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1760437 1 7.30
CHEMBL1760582 1 7.29
CHEMBL1760444 1 7.10
CHEMBL1760581 1 7.06
CHEMBL1760438 1 7.02
CHEMBL1760587 1 7.00
CHEMBL1760580 1 6.99
CHEMBL1760443 1 6.99
CHEMBL1760445 1 6.71
CHEMBL1760434 1 6.57
CHEMBL1760439 1 6.48
CHEMBL1760442 1 6.45
CHEMBL1760441 1 6.44
CHEMBL1760440 1 6.39
CHEMBL1760586 1 6.32
CHEMBL1760583 1 6.20
CHEMBL1760435 1 6.08
CHEMBL1760436 1 5.84
CHEMBL1760584 1 -
CHEMBL1760585 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1760437 EC50 = 50.0 nM 7.30
CHEMBL1760582 EC50 = 51.0 nM 7.29
CHEMBL1760444 EC50 = 79.0 nM 7.10
CHEMBL1760581 EC50 = 87.0 nM 7.06
CHEMBL1760438 EC50 = 95.0 nM 7.02
CHEMBL1760587 EC50 = 99.0 nM 7.00
CHEMBL1760580 EC50 = 102.0 nM 6.99
CHEMBL1760443 EC50 = 103.0 nM 6.99
CHEMBL1760445 EC50 = 193.0 nM 6.71
CHEMBL1760434 EC50 = 269.0 nM 6.57
CHEMBL1760439 EC50 = 328.0 nM 6.48
CHEMBL1760442 EC50 = 352.0 nM 6.45
CHEMBL1760441 EC50 = 366.0 nM 6.44
CHEMBL1760440 EC50 = 411.0 nM 6.39
CHEMBL1760586 EC50 = 474.0 nM 6.32
CHEMBL1760583 EC50 = 633.0 nM 6.20
CHEMBL1760435 EC50 = 833.0 nM 6.08
CHEMBL1760436 EC50 = 1440.0 nM 5.84
CHEMBL1760584 EC50 > 4000.0 nM -
CHEMBL1760585 EC50 > 4000.0 nM -