Assay Detail
Functional
CHEMBL1764175
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Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.57 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760478 | — | — | 1 | 5.52 |
| CHEMBL1760477 | — | — | 1 | 5.10 |
| CHEMBL1760476 | — | — | 1 | 4.77 |
| CHEMBL236906 | — | — | 1 | 4.66 |
| CHEMBL1760480 | — | — | 1 | 4.52 |
| CHEMBL237111 | AKBA | -1.0 | 1 | 4.51 |
| CHEMBL267225 | BOSWELLIC ACID | 2.0 | 1 | 4.46 |
| CHEMBL1760475 | — | — | 1 | 4.46 |
| CHEMBL1760466 | — | — | 1 | 4.40 |
| CHEMBL1760471 | — | — | 1 | 4.36 |
| CHEMBL1760484 | — | — | 1 | 4.35 |
| CHEMBL1760468 | — | — | 1 | 4.30 |
| CHEMBL1760473 | — | — | 1 | 4.30 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | — | 1 | 4.30 |
| CHEMBL1760481 | — | — | 1 | - |
| CHEMBL1760482 | — | — | 1 | - |
| CHEMBL1760483 | — | — | 1 | - |
| CHEMBL1760485 | — | — | 1 | - |
| CHEMBL1760486 | — | — | 1 | - |
| CHEMBL1760479 | — | — | 1 | - |
| CHEMBL1760474 | — | — | 1 | - |
| CHEMBL1760472 | — | — | 1 | - |
| CHEMBL1760470 | — | — | 1 | - |
| CHEMBL1760469 | — | — | 1 | - |
| CHEMBL1760467 | — | — | 1 | - |
| CHEMBL1760465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760478 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1760477 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1760476 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL236906 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1760480 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL237111 | AKBA | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL267225 | BOSWELLIC ACID | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1760475 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1760466 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1760471 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1760484 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1760468 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1760473 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1760481 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760482 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760483 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760485 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760486 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760479 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760474 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760472 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760470 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760469 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760467 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1760465 | — | IC50 | > | 50000.0 | nM | - |