Assay Detail
Functional
CHEMBL1764225
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Antagonist activity at CB1 receptor transfected in CHO cells expressing apoaequorin as a reporter for G-protein-coupled receptor-mediated calcium signaling by bioluminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.34 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 8.40 |
| CHEMBL445022 | VOACAMINE | — | 1 | 7.39 |
| CHEMBL1760377 | — | — | 1 | 6.85 |
| CHEMBL1760376 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL445022 | VOACAMINE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1760377 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL1760376 | — | IC50 | = | 199.0 | nM | 6.70 |