Assay Detail
Functional
CHEMBL1764348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Partial agonist activity at human PPARgamma expressed in CHO cells co-transfected with Gal4-responsive luciferase reporter plasmid after 24 hrs by transactivation assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological evaluation of novel benzoylazole-based PPAR α/γ activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.65 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760559 | — | — | 1 | 6.89 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.41 |
| CHEMBL1760558 | — | — | 1 | 5.77 |
| CHEMBL1760557 | — | — | 1 | 5.52 |
| CHEMBL1760561 | — | — | 1 | 5.48 |
| CHEMBL1760554 | — | — | 1 | 5.34 |
| CHEMBL1760556 | — | — | 1 | 5.32 |
| CHEMBL1760560 | — | — | 1 | 5.22 |
| CHEMBL1760555 | — | — | 1 | 4.92 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | - |
| CHEMBL1760553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760559 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL595 | PIOGLITAZONE | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1760558 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1760557 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1760561 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1760554 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1760556 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1760560 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1760555 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | - | — | - | |
| CHEMBL1760553 | — | EC50 | > | 10000.0 | nM | - |