Assay Detail
Functional
CHEMBL1764490
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Antitumor activity against human KB cells by WST-1 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The solvolysis of topotecan in alcohols and acetic anhydride.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.49 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760001 | — | — | 1 | 6.10 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | 6.08 |
| CHEMBL1760032 | — | — | 1 | 5.94 |
| CHEMBL1760031 | — | — | 1 | 5.86 |
| CHEMBL1760030 | — | — | 1 | 5.14 |
| CHEMBL10376 | — | — | 1 | 4.71 |
| CHEMBL1760029 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760001 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL1760032 | — | IC50 | = | 1151.0 | nM | 5.94 |
| CHEMBL1760031 | — | IC50 | = | 1376.0 | nM | 5.86 |
| CHEMBL1760030 | — | IC50 | = | 7246.0 | nM | 5.14 |
| CHEMBL10376 | — | IC50 | = | 19727.0 | nM | 4.71 |
| CHEMBL1760029 | — | IC50 | = | 25367.0 | nM | 4.60 |