Assay Detail
Functional
CHEMBL1764491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human HepG2 cells by WST-1 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The solvolysis of topotecan in alcohols and acetic anhydride.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.47 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760031 | — | — | 1 | 6.10 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | 6.01 |
| CHEMBL1760001 | — | — | 1 | 6.00 |
| CHEMBL1760032 | — | — | 1 | 5.88 |
| CHEMBL10376 | — | — | 1 | 5.41 |
| CHEMBL1760030 | — | — | 1 | 4.87 |
| CHEMBL1760029 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760031 | — | IC50 | = | 802.0 | nM | 6.10 |
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | = | 981.0 | nM | 6.01 |
| CHEMBL1760001 | — | IC50 | = | 1004.0 | nM | 6.00 |
| CHEMBL1760032 | — | IC50 | = | 1306.0 | nM | 5.88 |
| CHEMBL10376 | — | IC50 | = | 3909.0 | nM | 5.41 |
| CHEMBL1760030 | — | IC50 | = | 13480.0 | nM | 4.87 |
| CHEMBL1760029 | — | IC50 | = | 92071.0 | nM | 4.04 |