Assay Detail
Binding
CHEMBL1764565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of rat liver MAO-A after 60 mins using p-tyramine as substrate by spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.65 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760713 | — | — | 1 | 7.70 |
| CHEMBL1760721 | — | — | 1 | 7.36 |
| CHEMBL1760718 | — | — | 1 | 7.11 |
| CHEMBL1760719 | — | — | 1 | 7.02 |
| CHEMBL1760722 | — | — | 1 | 6.64 |
| CHEMBL1760720 | — | — | 1 | 6.62 |
| CHEMBL1760715 | — | — | 1 | 6.50 |
| CHEMBL1760714 | — | — | 1 | 6.41 |
| CHEMBL1760716 | — | — | 1 | 6.41 |
| CHEMBL1760717 | — | — | 1 | 6.40 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760713 | — | Ki | = | 20.14 | nM | 7.70 |
| CHEMBL1760721 | — | Ki | = | 43.9 | nM | 7.36 |
| CHEMBL1760718 | — | Ki | = | 77.61 | nM | 7.11 |
| CHEMBL1760719 | — | Ki | = | 95.65 | nM | 7.02 |
| CHEMBL1760722 | — | Ki | = | 230.3 | nM | 6.64 |
| CHEMBL1760720 | — | Ki | = | 241.54 | nM | 6.62 |
| CHEMBL1760715 | — | Ki | = | 320.13 | nM | 6.50 |
| CHEMBL1760714 | — | Ki | = | 385.26 | nM | 6.41 |
| CHEMBL1760716 | — | Ki | = | 389.49 | nM | 6.41 |
| CHEMBL1760717 | — | Ki | = | 396.57 | nM | 6.40 |
| CHEMBL972 | SELEGILINE | Ki | = | 10566.0 | nM | 4.98 |