Assay Detail
Binding
CHEMBL1764623
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Competitive inhibition of human recombinant MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.30 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760721 | — | — | 1 | 9.51 |
| CHEMBL1760713 | — | — | 1 | 8.94 |
| CHEMBL1760722 | — | — | 1 | 8.77 |
| CHEMBL1760715 | — | — | 1 | 8.74 |
| CHEMBL1760716 | — | — | 1 | 8.45 |
| CHEMBL1760717 | — | — | 1 | 8.38 |
| CHEMBL1760719 | — | — | 1 | 8.26 |
| CHEMBL1760720 | — | — | 1 | 8.24 |
| CHEMBL1760718 | — | — | 1 | 8.13 |
| CHEMBL1760714 | — | — | 1 | 8.12 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760721 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL1760713 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL1760722 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1760715 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL1760716 | — | Ki | = | 3.56 | nM | 8.45 |
| CHEMBL1760717 | — | Ki | = | 4.21 | nM | 8.38 |
| CHEMBL1760719 | — | Ki | = | 5.54 | nM | 8.26 |
| CHEMBL1760720 | — | Ki | = | 5.75 | nM | 8.24 |
| CHEMBL1760718 | — | Ki | = | 7.35 | nM | 8.13 |
| CHEMBL1760714 | — | Ki | = | 7.51 | nM | 8.12 |
| CHEMBL972 | SELEGILINE | Ki | = | 1960.0 | nM | 5.71 |